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Centrin 2

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Jan 16, 2022

Centrin-2 is a protein that in humans is encoded by the CETN2gene.[5][6][7] It belongs to the centrin family of proteins.

CETN2
Available structures
PDB Ortholog search: PDBeRCSB
List of PDB id codes

1M39, 1ZMZ, 2A4J, 2GGM, 2K2I, 2OBH

Identifiers
Aliases CETN2, CALT, CEN2, centrin 2
External IDs OMIM: 300006MGI: 1347085HomoloGene: 55798GeneCards: CETN2
Gene location (Human)
Chr. X chromosome (human)[1]

Band Xq28 Start 152,826,994 bp[1]
End 152,830,757 bp[1]
Gene location (Mouse)
Chr. X chromosome (mouse)[2]

Band X A7.3|X 37.29 cM Start 72,913,532 bp[2]
End 72,918,411 bp[2]
RNA expression pattern
Bgee
Top expressed in
  • cerebellum
  • fallopian tube
  • caput epididymis
  • peritoneum
  • pituitary gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez

1069

26370

Ensembl

ENSG00000147400

ENSMUSG00000031347

UniProt

P41208

Q9R1K9

RefSeq (mRNA)

NM_004344

NM_019405

RefSeq (protein)

NP_004335

NP_062278

Location (UCSC) Chr X: 152.83 – 152.83 Mb Chr X: 72.91 – 72.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrin-2 belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that centrin-2 plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.[7]

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CETN2 has been shown to interact with XPC[8] and SFI1.[9]

  1. GRCh38: Ensembl release 89: ENSG00000147400Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031347Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tanaka T, Okui K, Nakamura Y (May 1995). “Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization”. Genomics. 24 (3): 609–10. PMID 7713520.
  6. Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). “Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions”. Mamm Genome. 6 (11): 802–4. doi:10.1007/BF00539008. PMID 8597638. S2CID 19420279.
  7. “Entrez Gene: CETN2 centrin, EF-hand protein, 2”.
  8. Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). “Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair”. J. Biol. Chem. United States. 276 (22): 18665–72. doi:10.1074/jbc.M100855200. ISSN 0021-9258. PMID 11279143.
  9. Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). “Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex”. Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500.

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